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After a cardiac catheterization, the loss of pulse in the extremity is a significant and concerning sign that could indicate a complication, specifically potential vascular injury or occlusion at the access site. This loss of pulse suggests that blood flow to that extremity may be compromised, which can lead to ischemia if not promptly addressed.

Monitoring pulse in the extremities post-procedure is essential, as it reflects the adequacy of blood circulation. If a nurse identifies a loss of pulse, immediate assessment and intervention should follow to relive the obstruction and restore perfusion, as this can prevent further complications such as tissue necrosis or limb loss.

Increased blood pressure and heart rate can occur due to various factors, including pain, anxiety, or fluid shifts, and while they may suggest a response to stress or other conditions, they do not directly indicate a complication related to the catheterization itself. Similarly, decreased urine output can signal various issues such as dehydration or renal function changes, but it is not a definitive sign of a complication specifically related to the procedure in the immediate postoperative context. Thus, the loss of pulse in the extremity is the most critical indicator that should alert healthcare staff to a potential complication that requires immediate attention.