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Orthostatic hypotension is a significant concern in patients taking antipsychotic medications primarily because it can lead to dizziness when the patient transitions from sitting or lying down to standing up. This condition occurs due to a sudden drop in blood pressure, which may not be adequately compensated by the body’s normal physiological responses. The dizziness that accompanies orthostatic hypotension can increase the risk of falls and subsequent injuries, particularly in vulnerable populations such as the elderly or those with additional health issues. Recognizing and managing this side effect is crucial in ensuring the safety and wellbeing of patients on antipsychotic therapy.

While dehydration can be associated with orthostatic hypotension, it is not the sole cause; therefore, indicating dehydration is not the primary concern here. Similarly, hypertension is actually the opposite of what occurs with orthostatic hypotension. Although fatigue might be a symptom experienced by some patients, it is not the most immediate and clear concern that orthostatic hypotension presents, as dizziness has more direct implications for patient safety.